Dianabol (Methandrostenolone)

The Original Dianabol

Since 2008,  “Dianabol” is a registered trademark for a dietary supplement used for bodybuilding. The “original Dianabol product developed in 1955 by CIBA,contained a chemical called “methandrostenolone”, which was only available by prescription. Today there are many black market  products available containing this ingredient. Metandienone, also known as methandienone or methandrostenolone was once sold under the brand name Dianabol among others, is an androgen and anabolic steroid (AAS) medication which is mostly no longer used. It is also used non-medically for physique- and performance-enhancing purposes.It is taken by mouth.

Side effects of metandienone include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire, estrogenic effects like fluid retention and breast enlargement, and liver damage. The drug is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT), and has strong anabolic effects and moderate androgenic effects. It also has moderate estrogenic effects.

Metandienone was originally developed in 1955 by CIBA and marketed in Germany and the United States.As the CIBA product Dianabol, metandienone quickly became the first widely used AAS among professional and amateur athletes, and remains the most common orally active AAS for non-medical use. It is currently a controlled substance in the United Statesand United Kingdom[13] and remains popular among bodybuilders. Metandienone is readily available without a prescription in certain countries such as Mexico, and is also manufactured in some Asian countries.

However buying, selling, using, and possessing them constitutes a felony within the United States.  None produced in true pharmaceutical labs. The good news is that there are legal steroids supplements available which are safe. Legal to purchase and use, and they are extremely effective for use in muscle building and fat loss.

 

Methandrostenolone (trade names Averbol, Dianabol, Danabol), also known as metandienone (INN), methandienone. Informally as dianabol, is an orally-effective anabolic steroid originally developed in Germany. Released in the US in the early 1960s by Ciba Specialty Chemicals. Methandrostenolone is a controlled substance in the United States and Western Europe and remains popular among bodybuilders. An injectable form is sold online from United States based companies. Methandrostenolone is readily available without a prescription in countries such as Mexico. (under the trade name Reforvit-b), Also manufactured in Asia and many East European countries.

Biophysiology

Methandrostenolone binds tightly to the androgen receptor in order to exert its effects.[4] These include dramatic increases in protein synthesis, glycogenolysis, and muscle strength over a short space of time. Side effects such as gynecomastia, highblood pressure, acne and male pattern baldness may begin to occur. The drug causes severe masculinising effects in women even at low doses. In addition, it is metabolized into methylestradiol by aromatase. This means that without the administration of aromatase inhibitors.  Like anastrozole or aminoglutethimide, estrogenic effects will appear over time in men. Many users will combat the estrogenic side effects with Arimidex, Nolvadex or Clomid. In addition, as with other 17α-alkylated steroids, the use of methandrostenolone over extended periods of time can result in liver damage without appropriate care.

The 17α-methylation of the steroid does allow it to pass through the liver with only a small portion of it broken down (hence causing the aforementioned damage to the liver) allowing it to be effective when taken orally. It also has the effect of decreasing the steroid’s affinity for sex hormone binding globulin, a protein that de-activates steroid molecules and prevents them from further reactions with the body.

As a result, methandrostenolone is significantly more active than an equivalent quantity of testosterone, resulting in rapid growth of muscle tissue. However, the concomitant elevation in estrogen levels – a result of the aromatization of methandrostenolone – results in significant water retention. This gives the appearance of bad gains in mass and strength, which prove to be temporary once the steroid  discontinued and water weight drops. Because of this, it is often used by bodybuilders only at the start of a “steroid cycle“, to facilitate rapid strength increases and the appearance of great size, while compounds such as testosterone cypionate or testosterone enanthate with long acting esters build up in the body to an appreciable amount capable of supporting anabolic function on their own.

As a tonic

17α-methandrostenolone was discontinued by the DEA in 2008.

In the early 1960s, doctors commonly prescribed 3 tablets per day for women as a tonic. This use was quickly discontinued upon discovery of the heavily masculinising effects of methandrostenolone.

Bodybuilding

Despite the lack of any known therapeutic applications, the drug methandrostenolone remained legal until 2001. The United States Congress added certain kinds of steroids which may or may not include methandrostenolone  to the Controlled Substances Act as an amendment known as the Anabolic Steroid Control Act of 1990. This act placed steroids in the same category as some amphetamines as a “Schedule III” drug and possession of these drugs results in a felony. Bodybuilders still use methandrostenolone illegally to this day, typically combined (stacked) with injectable compounds, like testosterone propionate, enanthate, cypionate as well as other injectable drugs like trenbolone acetate.

Several successful athletes and professional bodybuilders came forward and admitted long-term methandrostenolone use before the drug banned, including Arnold Schwarzenegger. Other steroids stacked with methandrostenolone are primarily, if not always, injectable compounds such as testosterone, trenbolone and nandrolone. Large doses and long-term use of methandienone, associated with eccentric left-ventricular hypertrophy which presents substantially increased risks of cardiomyopathy if and when the hypertrophy atrophies. Athleticism, typically associated with left-ventricular hypertrophy however natural athleticism generally presents concentric left-ventricular growth  not linked to an increased risk of cardiomyopathy.

Detection of use

Methandrostenolone, subject to extensive hepatic biotransformation by a variety of enzymatic pathways. The primary urinary metabolites, detectable for up to 3 days, and a recently discovered hydroxymethyl metabolite, found in urine for up to 19 days after a single 5 mg oral dose. Several of the metabolites are unique to methandrostenolone. Methods for detection in urine specimens usually involve gas chromatography-mass spectrometry.

History

For a period of time John Bosley Ziegler worked at the Ciba Pharmaceutical company, who supplied testosterone for experimental purposes. In the early 1950s his patients included people suffering from burns, as well as the seriously injured or handicapped. In 1954 he administered testosterone. For a period of less than 6 weeks, to several high-level competitive bodybuilders. On an experimental basis, but had disappointing results. Dissatisfied and possibly overburdened with patients. He distanced himself from research into performance-enhancing drugs until May 1960, or possibly as early as 1959 (conflicting testimonials).

By the time of the 1960 European Championships in Milan, understandably suspicious of the Russians. “The Russians give their athletes something.” Therefore, he asked John Grimek to propose to his chief, Bob Hoffman that steroids administered to members of the American Olympic team. Mr. Hoffman, however,  cautious and later remarked it was “too close to give to the men who will represent the USA”. According to Grimek, “Apparently, he doesn’t think it will do that much good.”  Instead, Dianabol, given to two lower level lifters to investigate its effectiveness and safety. After that, Hoffmann retracted his decision and Dianabol, administered to certain Weightlifters on the team.